J B Smith, C Ingerman, M J Silver
J Clin Invest.
1976;
58(5):1119–1122
doi:10.1172/JCI108564
This article Copyright © 1976, The American Society for Clinical Investigation
Abstract
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D
uring the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material. This material persists in plasma because of its continued production and increased stability.
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