Published in Volume
53, Issue 4 (April 1974)
J Clin Invest. 1974;53(4):1197–1201.
doi:10.1172/JCI107659.
Copyright ©
1974, The American Society for
Clinical Investigation.
Concise Publications
Superoxide Dismutase Activity in Leukocytes
Lawrence R. Dechatelet, Charles E. McCall, Linda C. McPhail and Richard B. Johnston, Jr.
Department of Biochemistry, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103Department of Medicine, The Bowman Gray School of Medicine, Winston-Salem, North Carolina 27103The Department of Pediatrics, The University of Alabama Medical Center, Birmingham, Alabama 25233
Published April 1974
Superoxide dismutase activity has been identified in both human neutrophils and rabbit alveolar macrophages by two distinct assay procedures. The enzyme is insensitive to both cyanide and azide and is present in the cytosol of the cell. The identification of this enzyme in phagocytic cells is compatible with the theory that superoxide anion might be involved in the bactericidal activity of the cell. It is proposed that the enzyme functions to protect the cell against superoxide generated during the phagocytic process.
Browse pages
Click on an image below to see the page. View
PDF of the complete article
