Published in Volume
52, Issue 11 (November 1973)
J Clin Invest. 1973;52(11):2853–2857.
doi:10.1172/JCI107481.
Copyright ©
1973, The American Society for
Clinical Investigation.
Articles
In Vivo Suppression of the Immune Response to Alloantigen by Cholera Enterotoxin
Christopher S. Henney, Lawrence M. Lichtenstein, Elizabeth Gillespie and Ronald T. Rolley
Department of Medicine of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239Department of Surgery of the Johns Hopkins University School of Medicine and the O'Neill Memorial Laboratories of the Good Samaritan Hospital, Baltimore, Maryland 21239
Published November 1973
The immune response of C57BL/6 mice to allogeneic (DBA/2) mastocytoma cell suspensions was profoundly suppressed by intraperitoneal administration of 1 μg cholera enterotoxin 4 days after antigenic stimulation. The immune response assayed 11 days after antigen showed decreased cytolytically active thymusderived (T) lymphocytes and markedly depressed serumagglutinating titers. A comparable suppression of the immune response to skin allografts (DBA/2→C57BL/6) was also effected by cholera toxin administration, although there was no prolongation of allograft survival.
The mechanism of the immune suppression is apparently related to the known adenylate cyclase stimulatory activities of choleragen.
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