Jean E. Russell, John D. Termine, Louis V. Avioli
J Clin Invest.
1973;
52(11):2848–2852
doi:10.1172/JCI107480
This article Copyright © 1973, The American Society for Clinical Investigation
Abstract
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-ray diffraction analysis of bone from chronically uremic but nonacidotic rats with normocalcemia and hyperphosphatemia revealed smaller apatite crystals and an increase in the X-ray amorphous mineral fraction when compared to age-matched, pair-fed control animals, indicating less advanced mineral maturation in the uremic animals. Studies in animals with varied degrees of chronic renal insufficiency revealed a progression of the bone crystal maturational defect with advancing uremia.
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