Published in Volume
51, Issue 7 (July 1972)
J Clin Invest. 1972;51(7):1927–1931.
doi:10.1172/JCI106998.
Copyright ©
1972, The American Society for
Clinical Investigation.
Concise Publications
Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier
Harvey R. Colten and Kenneth H. Gabbay
Division of Allergy, Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115Division of Immunology, Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115Division of Endocrinology, Department of Medicine, Children's Hospital Medical Center, Boston, Massachusetts 02115Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115
Published July 1972
Cytochalasin B, a metabolic product of several fungi, enhances up to 10-fold the sensitivity and reactivity of human leukocytes to antigen E or anti-IgE-mediated histamine release. The effect of cytochalasin B is a result of its action on the second, antigen-independent, stage of histamine release. These data suggest that normally, antigen-triggered histamine release is modulated by a cytochalasin-sensitive barrier (CSB). This CSB modulation of histamine release can be separated from the modulating effect of cyclic adenosine monophosphate (AMP).
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