Ann J. Woolcock, N. J. Vincent, Peter T. Macklem
J Clin Invest.
1969;
48(6):1097–1106
doi:10.1172/JCI106066
This article Copyright © 1969, The American Society for Clinical Investigation
Abstract
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e selected five bronchitics and four asthmatics in remission, whose routine lung function tests were not significantly abnormal. Dynamic compliance was measured at different respiratory frequencies and the results compared with those obtained from a normal control group. In all patients compliance was frequency dependent and remained so after the administration of bronchodilator aerosols. Compliance was frequency dependent in only one normal subject, and this was completely reversed by bronchodilators. Because the elastic properties of the patients' lungs were normal, and because pulmonary resistance was normal or only minimally increased, we interpret these results as indicating obstruction in peripheral airways.
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