Published in Volume
46, Issue 9
(September 1967)J Clin Invest.
1967, The American Society for
Studies of the Metabolic Activity of Leukocytes from Patients with a Genetic Abnormality of Phagocytic Function*
Pediatrics Research Laboratories of the Variety Club Heart Hospital, Minneapolis, MinnesotaDepartment of Pediatrics, University of Minnesota, Minneapolis, MinnesotaDepartment of Microbiology, University of Minnesota, Minneapolis, Minnesota
‡ Research Assistant, U. S. Public Health Service Training Grant in Medical Microbiology AI 90-06.
§ Associate Professor, Career Development Awardee of the U. S. Public Health Service.
ǁ American Legion Memorial Heart Research Professor of Pediatrics and Microbiology.
* Submitted for publication 18 January 1967; accepted 5 June 1967.
Published September 1967
Polymorphonuclear leukocytes from patients with chronic granulomatous disease respond to the phagocytosis of latex particles with normal increments in glucose consumption, lactate production, Krebs' cycle activity, and lipid turnover.
The leukocytes of these patients fail to show normal increments in respiration, direct oxidation of glucose, and hydrogen peroxide formation during particle uptake.
It appears that the stimulation of respiration with the formation of hydrogen peroxide and stimulation of the direct oxidative pathway of glucose metabolism are closely linked to degranulation and intracellular killing of bacteria by polymorphonuclear leukocytes.
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