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PATHOGENESIS OF THE COAGULATION DEFECT DEVELOPING DURING PATHOLOGICAL PLASMA PROTEOLYTIC (“FIBRINOLYTIC”) STATES. I. THE SIGNIFICANCE OF FIBRINOGEN PROTEOLYSIS AND CIRCULATING FIBRINOGEN BREAKDOWN PRODUCTS*

Anthony P. Fletcher, Norma Alkjaersig and Sol Sherry

Department of Medicine, Washington University School of Medicine, St. Louis, Mo.

* This work was supported by a grant from the National Heart Institute (H3745), United States Public Health Service, Bethesda, Md. Presented in part at the Fifty-first National Meeting of the American Society for Clinical Investigation, Atlantic City, N. J., May, 1959 (J. clin. Invest. 1959, 38, 1005) and at the Thirty-third Annual Meeting of the Central Society for Clinical Research, Chicago, Ill., October, 1960 (J. Lab. clin. Med. 1960, 56, 813).

Published April 1962

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