A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality
J. Clin. Invest. Val Mann, et al. 107:899 doi:10.1172/JCI10347 [Go to this article.]

Figure 5
Relationship between COL1A1 alleles and material properties of bone. Bone samples from various sites in the femoral head (a) derived from “Ss” heterozygotes had significantly reduced yield strength when compared with samples derived from “SS” homozygotes (b), but there was no significant difference in density of the bone cores according to genotype (c). Values are expressed as mean ± SD. MPa, megapascals.