A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality
J. Clin. Invest. Val Mann, et al. 107:899 doi:10.1172/JCI10347 [
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Figure 5Relationship between
COL1A1 alleles and material properties of bone. Bone samples from various sites in the femoral head (
a) derived from “Ss” heterozygotes had significantly reduced yield strength when compared with samples derived from “SS” homozygotes (
b), but there was no significant difference in density of the bone cores according to genotype (
c). Values are expressed as mean ± SD. MPa, megapascals.