A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality
J. Clin. Invest. Val Mann, et al. 107:899 doi:10.1172/JCI10347 [Go to this article.]

Figure 1
Meta-analysis of COL1A1 polymorphisms in relation to BMD and osteoporotic fractures. (a) Standardized mean difference (SMD) and 95% confidence intervals between the “SS” and “Ss” genotype groups for lumbar spine bone density (LS BMD). (b) Corresponding data for the “SS” versus “ss” genotype comparison. Also shown are the number of individuals studied, the mean and SD BMD values in each genotype group, and the weight and confidence intervals for individual studies. The results of heterogeneity testing and tests for overall effect are shown at the bottom left of each panel. Note that data from both populations studied by Grant et al. (3) are shown separately as Grant 1996a and Grant 1996b. (c) Odds ratios for fracture for the “SS” versus “Ss” genotype comparison. (d) Corresponding data for the “SS” versus “ss” comparison. Numbers in the cases and controls columns refer to the number of individuals with the risk genotype (“Ss” or “ss”) in relation to the total number of individuals studied. In the study of Uitterlinden et al. (8), data on both vertebral and nonvertebral fractures were available, and these are shown respectively as Uitterlinden 1998a and Uitterlinden 1998b.