Treatment of murine lupus with cDNA encoding IFN-γR/Fc
J. Clin. Invest. Brian R. Lawson, et al. 106:207 doi:10.1172/JCI10167 [
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Figure 1Serum IFN-γ levels for treatment and control groups. Levels were determined by solid-phase ELISA. (
a) Treatments initiated at 1 month of age without local electroporation. (
b) Treatments initiated at 1 month of age with electroporation. (
c) Treatments initiated at 4 months of age with electroporation. Circles, no treatment; squares, blank plasmid (VR1255); triangles, active plasmid (VR1255-IFN-γR/Fc). The mean and SEM are shown. In
a,
P < 0.001, and in
b and
c,
P < 10
–6 between active plasmid– and blank plasmid–treated groups (
n = 3–8).